Epicureanism sees striving for knowledge as disruptive of human happiness. It tries to tame this striving by showing that all possible explanations of natural events are equivalent in their consequences for man -- hence the actual state of affairs can be a matter of indifference.
Negative valuation of curiosity. Views man as having a natural state of happy obliviousness that is shattered by curiosity about the heavens (contrast with Stoic admiration for and taking comfort in the regularity of the the heavens).
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